Effects of reserpine and guanethidine on venous reflexes.

Effects of Guanethidine, Reserpine, and Methyldopa on Reflex Venous and Arterial Constriction in Man.

Persistence of reflex sympathetic nervous system activity in man on guanethidine or reserpine.

SUMMARY The effect of guanethidine and reserpine on the reflex sympathetic nervous system vasoconstriction in the calf and foot induced by a prolonged, generalized stimulus (body cooling for 1 hour) was studied in 12 normal subjects. Large daily clinical-doses of guanethidine (40 to 60 mg) or reserpine (1 mg) were given orally for 2 and 3 weeks, respectively. Foot and calf blood flows were meas...

Patient acceptance of guanethidine as therapy for mild to moderate hypertension. A comparison with reserpine.

The relative benefits and risks of reserpine and guanethidine were compared in patients with thiazide-treated mild to moderate hypertension (diastolic pressure 95-115 mm Hg). Forty-nine ambulant patients )30 men, 19 women) were treated throughout the study with hydrochlorothiazide, 50 mg/day. In this double blind crossover study each drug was added in graded increments until a predetermined the...

Hemodynamic effects of guanethidine in man.

• Guanethidine is a potent antihypertensive agent with selective inhibitory effects on the syinpathetic nervous system. 1 It provides effective reduction of blood pressure without the troublesome side effects of parasympa-thetic blockade associated with ganglionie blocking drugs. 2 Decreased blood pressure in supine patients following guanethidine has been associated with a fall in cardiac outp...

Rauwolfia and guanethidine: pharmacology and clinical use in treatment of hypertension.

B Y COINCIDENCE, reserpine, which is the oldest and weakest, and guanethidine, which is the latest and most potent of the modern antihypertensive drugs, share a common basic pharmacologic action. Both agents lead to depletion of the body stores of norepinephrine and thus, to varying degrees, interference with the function of the sympathetic nervous system.1-4 The precise mechanism by which they...